Theracurmin: A Major Breakthrough in Turmeric's Potent Curcumin Pharmacology

By Guest

Curcumin is the yellow pigment of turmeric (Curcuma longa) – the chief ingredient in Indian curry seasoning – and one of the most intensely studied natural products available today. As of March 2015, more than 5,000 scientific studies have focused on curcumin. While curcumin has demonstrated significant activity in many experimental and clinical studies, its primary biological effects relate to its actions as a broad-spectrum antioxidant and profound anti-inflammatory agent.

Curcumin has shown measurable anti-inflammatory activity in a variety of experimental models as well as clinical studies. In fact, in numerous studies curcumin’s anti-inflammatory effects were comparable to the drugs hydrocortisone and phenylbutazone, as well as over-the-counter anti-inflammatories such as ibuprofen. Clinical studies have further substantiated curcumin’s anti-inflammatory effects. While most anti-inflammatory drugs only impact one or two of the mediators of inflammation, curcumin exerts actions against all of them.

While there is a lot of excitement around curcumin, there is also some concern that clinical results will not be as impressive as preclinical studies in cell cultures and in animal models due to the fact that regular curcumin is poorly absorbed by the human body, and rapidly metabolized and eliminated. Dosages as high as 12 g have failed to significantly raise blood levels. Fortunately, now there’s a curcumin product that has overcome the challenge of poor bioavailability.

The most bioavailable form of curcumin

Theracurmin is an all-natural preparation that utilizes advanced techniques to reduce the particle size of curcumin and dramatically increase its solubility. With Theracurmin, the average particle size is 0.19 to 0.3 μm, approximately 100 times smaller than the average curcumin powder particle size of 22.75 μm.

This reduced-particle-sized curcumin is provided in a colloidal suspension to dramatically increase its solubility in water. The result is an unparalleled increase in the absorption of curcumin compared to all other commercial forms tested, including other enhanced forms of curcumin. At equal dosage levels, Theracurmin produces blood levels that are significantly higher than those produced by any other form of curcumin.

Read more about the health benefits of turmeric and other spices

Enhanced benefits

Because Theracurmin enhances the absorption of curcumin, all of the benefits associated with curcumin are also enhanced. Theracurmin has been the subject of several clinical studies that have shown superior effects. Specifically, Theracurmin possesses the ability to reduce tissue damage caused by inflammation, improve liver function, increase the ability of the heart to function more efficiently, increase the flexibility of the arteries, improve joint function, and improve quality of life scores in cancer patients.

Clearly curcumin is an extremely unique and interesting molecule, which is why researchers around the world have devoted so much attention to understanding its action. Now, with Theracurmin, they finally have access to a form of curcumin that will allow them to achieve the same sort of blood levels shown to be effective in preclinical studies.

Read more about fighting inflammation with food


Michael T. Murray, ND, is widely regarded as one of the world’s leading authorities on natural medicine. He is the author of over 30 books, including co-author of the best-selling The Encyclopedia of Natural Medicine, and Director of Product Science and Innovation for Natural Factors. www.DoctorMurray.com.

References:
Kanai M, Imaizumi A, Otsuka Y, et al. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol. 2012 Jan;69(1):65-70.
Kanai M, Otsuka Y, Otsuka K, et al. A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients. Cancer Chemother Pharmacol. 2013 Jun;71(6):1521-30.
Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, J Orthop Sci. 2014 Nov;19(6):933-9.
Sasaki H, Sunagawa Y, Takahashi K, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34(5):660-5.
Shimatsu A, Kakeya H, Imaizumi A, et al. Clinical application of "curcumin", a multi-functional substance. Anti-Aging Med, 2012 March;9(2):75-83
Sugawara J, Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. Am J Hypertens. 2012 Jun;25(6):651-6.
Takahashi M, Suzuki K, Kim HK, et al. Effects of curcumin supplementation on exercise-induced oxidative stress in humans. Int J Sports Med. 2013;34:1-7

Image: Steven Jackson

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By Guest| June 26, 2015
Categories:  Care

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