Calcium D-Glucarate is a botanical extract found in cruciferous vegetables such as broccoli and Brussels sprouts, as well as apples, grapefruit, and oranges. Research is showing that this nutrient helps the body eliminate harmful substances and lowers abnormally high levels of hormones including estrogen, testosterone, and progesterone through a process called glucuronidation. This may help protect against the development of certain hormone-related tumors and cancer.
Estrogen dominance is a serious and prevalent health issue promoting symptoms of PMS, endometriosis, fibroids, and causing the growth of unhealthy tissues, such as breast tumors. Glucuronidation plays an active role in detoxifying estrogen and balancing the hormones testosterone and progesterone. Glucuronidation is a Phase II liver detoxification process that occurs when toxins or carcinogens are combined with water-soluble substances, passing them to the large intestine where the body can safely eliminate them.
Calcium D-glucarate supports glucuronidation by inhibiting an enzyme called beta-glucuronidase. When levels of this enzyme become elevated, the glucuronidation process is reversed and toxins and potentially dangerous hormones are released back into the bloodstream. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly breast, prostate, and colon cancers.
For hormone balancing, eat cruciferous vegetables at least three times a week. They provide calcium D-Glucarate and indole-3-carbinol, another substance that detoxifies hormones. If you choose to supplement, most formulas combine 200 mg of Calcium D-Glucarate and 25 mg of Calcium (as calcium d-glucarate).
